UDOPP

Research

UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) uses state of the art technologies and cutting edge research to help projects pre-clinically optimize compound series and deliver candidate drugs of the highest possible quality. UDOPP is located in professor Per Artursson´s research group at the Faculty of Pharmacy, Uppsala University, Uppsala, Sweden.

UDOPP objective is to support:

1. Academic/non-for-profit research groups.

2. Pharmaceutical biotech and big-pharma companies.

UDOPP offers knowledge, competences and experience within medicinal and physical chemistry, biopharmaceutics, bioanalysis, drug metabolism, pharmacokinetics, formulations, cell and molecular biology, and computational modeling.

In order to obtain more details about our offers please contact:
Pawel Baranczewski: e-mail: pawel.baranczewski@farmaci.uu.se; Tel: +46-18-471 4067; Mobil +46-707-467894

Academic partners

Through the establishment of collaboration with UDOPP, our academic partners gain access not only to established assays and relevant expertise, but also to new research and technologies that can have a significant impact on their projects.
The ability to screen a project’s candidates in our well validated in silico models gives our partners the chance to rapidly select a smaller set of compounds on which to perform a more complete in vitro analysis. Alternatively, when potential problems (e.g. solubility) are anticipated or have already been identified, more specialized in vitro assays can be performed in order to obtain a clearer picture of the compounds potential to obtain a sufficiently good ADMET profile in vivo.

Collaboration principles and opportunities

The platform aims to work together with our academic partners in a flexible manner and to be able to provide support throughout a project’s life at a pace that is suitable for both partners. In addition to providing in silico and in vitro data, the group’s scientific expertise can be utilized to add significant scientific value and help make key decisions about the next steps for the project.
Guidelines with respect to any publications and intellectual property that are generated during the course of the collaboration are established before the project is initiated.

UDOPP considers all projects on a case-by-case basis, and when working with not-for-profit partners we aim to provide a cost and time structure that is suited to the individual projects needs and capacity. Together with the project(s) sponsor, we can if required explore possibilities to fund the collaboration through grant applications and other types of external resources.

Project Management

The platform’s aim is to work together with our partners in a flexible and time efficient manner.
Timelines and resources for each project are assigned on an individual basis following discussions with the partner.

Clear guidelines with respect to cost, IP ownership, project reporting and the overall structure of the collaboration will be established before the project is initiated.
UDOPPs project manager coordinates all activities for each project and is the primary contact person for the partner.

Academic partnerships are handled through the national research infrastructures Chemical Biology Consortium Sweden (CBCS, www.cbcs.se) and Science for Life Laboratories (SciLifeLab, www.scilifelab.se). Please see the Research Infrastructure for more information or contact: In order to obtain more details about our offers please contact:
Pawel Baranczewski: e-mail: pawel.baranczewski@farmaci.uu.se; Tel: +46-18-471 4067; Mobil +46-707-467894

Industry partners

By establishing a long-term relationship with UDOPP, our partners gain access to world leading expertise and cutting edge research in the ADMET field.

We aim to provide our industrial partners with rapid results and data which will enable their projects to move forward as rapidly as possible.

These studies range from relatively straightforward measurements of parameters such as solubility, permeability and metabolic stability, to more advanced research projects dealing with biopharmaceutical classification, identification of transport mechanisms and prediction of their influence on pharmacokinetics, mapping the drug-drug interactions with transport proteins and design of formulations for in vivo experiments.

The work performed is of a professional quality and is documented to the level required by our partners.

Pricing Models

For the commercial organizations the full costs model is applied.
In order to obtain more details about our offers please contact:
Pawel Baranczewski: e-mail: pawel.baranczewski@farmaci.uu.se; Tel: +46-18-471 4067; Mobil +46-707-467894

UDOPP Vision

To add value to all stages of pharmaceutical and ADMET related research and thereby increase the number of drug candidates which can be successfully developed to marketed drugs.

Platform goals

1. To add high quality scientific value to chemistry and biological discovery and development projects.

2. To optimize the pharmaceutical profile of lead candidates through collaborative research programs together with academic/non-for-profit research groups and pharmaceutical and biotech companies.

3. To provide expert competence within drug optimization and pharmaceutical profiling to academic/non-for-profit research organizations as well as pharmaceutical and biotech companies.

4. To develop new predictive techniques and technologies with our partners in order to help support the drug discovery and development process within the ADMET field.

5. To continue to develop the unique competences available at the platform through stimulating and challenging research projects, and through hosting courses, seminars and symposia in this research field.

UDOPP is associated with the national research infrastructures the Chemical-Biology Consortium Sweden (CBCS, www.cbcs.se) and Science for Life Laboratories (SciLifeLab, www.scilifelab.se).

Research infrastructure

The Drug Delivery Research Group

We wish to understand drug absorption at the molecular and cellular level in order to deliver drugs more effectively via the oral route. We also focus on the distribution and function of important drug-transporting proteins in the human body in order to better understand drug disposition and drug interactions.

We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict oral drug absorption, to define rate-limiting barriers to the absorption and organ distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney.
We anticipate that our research will provide insights into new mechanisms for drug absorption, disposition and delivery, and, hopefully, suggest new therapeutic strategies for efficient oral drug delivery.

Please see Key Research Areas for more information about our current research efforts.

Chemical Biology Consortium Sweden (CBCS)

In 2010, UDOPP became one of three nodes of a new research infrastructure in Sweden, the Chemical Biology Consortium Sweden (CBCS).  CBCS is a government-funded, non-profit strategic resource for academic researchers across Sweden.  The organization coordinates, and makes available, a powerful academic framework of infrastructures for the discovery, development and utilization of small molecules and molecular probes for life-science application.  CBCS provides expertise within assay development, computational chemistry, cheminformatics, chemical library screening and development, medicinal chemistry, and preclinical profiling.

By providing access to state-of-the-art science and technology, CBCS aims to help Swedish academia towards new discoveries in fundamental aspects of biology.
For more information about CBCS see: www.cbcs.se/

Science for Life Laboratories (SciLifeLab)

Science for Life Laboratories (SciLifeLab) was established 2010 with support from the Swedish government. The major objective of the SlLifeLab is to serve as a national infrastructure for high-throughput (HTS) and technically advanced research in life science. The SciLifeLab organization included 350 researchers and 13 platform facilities (2012).

For more information please visit the LifeSciLab homepage: www.scilifelab.se

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