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The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP)

The identification of drug candidates suitable for pre-clinical and clinical development involves not only obtaining sufficient potency on the relevant biological pathway, but also ensuring the compound’s ADMET (absorption, distribution, metabolism, excretion, toxicity) properties are consistent with obtaining efficacy in vivo. Through the use of a battery in vitro assays it is possible to optimize the pre-clinical properties, giving the chosen candidate drug the best possible chance of success. UDOPP uses state of the art technologies and cutting edge research to help projects optimize compound series and deliver candidate drugs of the highest possible quality.

Within UDOPP competences within  medicinal and physical chemistry, biopharmaceutics, bioanalysis, pharmacokinetics, formulations, cell and molecular biology and computational modeling are currently available, all of which are of major importance for a careful analysis of the ADMET profile of new drug candidates.

Platform Vision

To add value to all stages of pharmaceutical and ADMET related research an thereby increase the number of drug candidates which can be successfully developed to marketed drugs.

Platform goals

1. To add high quality scientific value to chemistry and biological discovery and development projects
2. To optimize the pharmaceutical profile of lead candidates through collaborative research programs together with academic/non-for-profit research groups and pharmaceutical and biotech companies.
3. To provide expert competence within drug optimization and pharmaceutical profiling to academic/non-for-profit research organizations as well as pharmaceutical and biotech companies.
4. To develop new predictive techniques and technologies with our partners in order to help support the drug discovery and development process within the ADMET field.
5. To continue to develop the unique competences available at the platform through stimulating and challenging research projects, and through hosting courses, seminars and symposia in this research field